T2- and T1 relaxivities and magnetic hyperthermia of iron-oxide nanoparticles combined with paramagnetic Gd complexes.

Autor: STEPANOV, ALEXEY, FEDORENKO, SVETLANA, MENDES, RAFAEL, RÜMMELI, MARK, GIEBELER, LARS, WEISE, BRUNO, GEMMING, THOMAS, DUTZ, SILVIO, ZAHN, DIANA, ISMAEV, ILDUS, AMIROV, RUSTEM, KHOLIN, KIRILL, VOLOSHINA, ALEXANDRA, SAPUNOVA, ANASTASIYA, SOLOVIEVA, SVETLANA, MUSTAFINA, ASIYA
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Zdroj: Journal of Chemical Sciences; 2021, Vol. 133 Issue 2, p1-10, 10p
Abstrakt: The present paper reports the synthesis of iron-oxide nanoparticles (diameter 12.8±2.2 nm) coated with silica shell doped with paramagnetic Gd(III)-based complexes. The resulting nanoparticles with a silica shell thickness of about 45 nm have an average diameter of 113.1±14.3 nm and feature high transverse and longitudinal relaxivities (356 and 25 mM−1 s−1, respectively) at 1.5 T and 25 °C on a medical whole body NMR scanner. It has been also revealed using magnetic heating measurements that the prepared core-shell nanoparticles possess a high specific adsorption rate of around 236 W/g in aqueous media. The surface of the composite nanoparticles was decorated by amino-groups for a greater cellular uptake behaviour. The cell viability measurements reveal the concentration-dependent cytotoxicity of the nanoparticles, which agrees well with the high content of Gd(III) complexes in the nanomaterial. The obtained results show that the core-shell design of nanoparticles with superparamagnetic and paramagnetic parts can be promising for high transverse (and longitudinal) relaxivity as well as magnetic hyperthermia. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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