| Autor: |
Li, You-Fen, Chen, Zheng-Jun, Jiao, Wen-Ya, Chen, Zhi-Jiao, Chen, Lin |
| Předmět: |
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| Zdroj: |
Synlett; 2021, Vol. 32 Issue 9, p923-929, 7p |
| Abstrakt: |
The efficient organocatalyzed Michael/ammonolysis cascade reaction of N -protected 4-aminopyrazolones and α,β-unsaturated acyl phosphates has been developed. This tactic gives rise to architecturally multifarious spiro(2-oxopyrrolidinyl)-5,4′-pyrazolones in good productiveness (up to 88% yield) and with moderate to good diastereoselectivities (up to 20:1 dr). These novel hybrid heterocycles would be promising candidates for drug-discovery programs and chemical biology. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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