| Autor: |
Dardiotis, Efthimios, Rikos, Dimitrios, Siokas, Vasileios, Aloizou, Athina-Maria, Tsouris, Zisis, Sakalakis, Evagelos, Brotis, Alexandros G., Bogdanos, Dimitrios P., Hadjigeorgiou, Georgios M. |
| Předmět: |
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| Zdroj: |
International Journal of Neuroscience; Jun2021, Vol. 131 Issue 6, p544-548, 5p |
| Abstrakt: |
Α number of genetic variants are considered to confer susceptibility to Parkinson's disease (PD). Rs75392628 (R47H), a rare variant of TREM2 gene, has been linked to PD, although its role on PD remains conflicting. Detection of a possible contribution of rs75392628 variant of TREM2 gene to PD risk. A total of 358 PD patients and 358 healthy controls genotyped for rs75392628. In addition, a meta-analysis was performed by merging our results with those from previous studies. The rare variant of rs75932628 (47H) of TREM2 gene was not detected on cohort. Meta-analysis of a total of 9271 PD cases and 9777 controls across 14 independent PD data sets from 9 studies, including the present study, did not show any statistically significant effect of rs75392628 on PD risk (ORFE:1.54 95% CI:0.87-2.73. ORRE: 1.54, 95%CI: 0.71-3.32). Rs75392628 TREM2 variant is rather unlikely to be a major genetic risk contributor of PD. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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