Stunning Response with Low-Dose Enzalutamide after Abiraterone Acetate Failure in a Patient Diagnosed with Metastatic Castration-Resistant Prostate Cancer: A Case Report.

Autor: Rossi, Luigi, Cimino, Giuseppe, Gozzi, Elisa, Sinjari, Marsela, Brandi, Martina, Ceddia, Serena, Cosimati, Antonella, Raimondi, Lucrezia, Fontana, Antonella, Filippi, Luca, Bagni, Oreste, Spinelli, Gian Paolo
Předmět:
Zdroj: Case Reports in Oncology; 2021, Vol. 14 Issue 1, p634-640, 7p
Abstrakt: We report a case of an elderly patient with metastatic castration-resistant prostate cancer, initially treated with abiraterone acetate (1,000 mg/day) combined with LH-RH antagonist, prednisone (10 mg/day), and zoledronic acid to manage bone metastases. In consideration of his poor performance status, radiological and biochemical progression of the disease, we decided to switch abiraterone to enzalutamide (160 mg/day). Due to adverse events, we reduced enzalutamide to a dose of 80 mg/day. Currently, the disease is under control despite the use of a low dose of enzalutamide. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index