| Autor: |
Shimomura, Takahito, Nakajima, Tomoki, Nakashima, Toshiaki, Morimoto, Yasutaka, Yamaoka, Junko, Shibuya, Akiko, Ohno, Tomoyuki, Yoshida, Norimasa, Kishimoto, Mitsuo, Konishi, Eiichi, Tanaka, Hideo, Moriguchi, Michihisa, Itoh, Yoshito |
| Předmět: |
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| Zdroj: |
Case Reports in Gastroenterology; 2021, Vol. 15 Issue 1, p232-243, 12p |
| Abstrakt: |
A 79-year-old man presented with high fever, marked eosinophilia, altered biochemical liver function tests (LFT) with predominance of biliary enzymes, and severe wall thickening of the gallbladder. Magnetic resonance cholangiopancreatography (MRCP) suggested cholecystitis, without signs of biliary strictures. Laparoscopic cholecystectomy and exploratory liver excision revealed eosinophilic cholangitis and cholecystitis, complicated with hepatitis and portal phlebitis. Prednisolone monotherapy rapidly improved peripheral eosinophilia, but not LFT. Liver biopsy showed that infiltrating eosinophils were replaced by lymphocytes and plasma cells. Treatment with ursodeoxycholic acid improved LFT abnormalities. Nevertheless, after 2 months, transaminase-dominant LFT abnormalities appeared. Transient prednisolone dose increase improved LFT, but biliary enzymes' levels re-elevated and jaundice progressed. The second and third MRCP within a 7-month interval showed rapid progression of biliary stricture. The repeated liver biopsy showed lymphocytic, not eosinophilic, peribiliary infiltration and hepatocellular reaction to cholestasis. Eighteen months after the first visit, the patient died of hepatic failure. Autopsy specimen of the liver showed lymphocyte-dominant peribiliary infiltration and bridging fibrosis due to cholestasis. Though eosinophil-induced biliary damage was an initial trigger, repeated biopsy suggested that lymphocytes played a key role in progression of the disease. Further studies are needed to elucidate the relationship between eosinophils and lymphocytes in eosinophilic cholangitis. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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