| Autor: |
Varol, Aslıhan Bahadır, Esen, Emre Cem, Çakmaklı, Gül Yalçın, Kurşun, Hülya Karataş, Özkan, Müge Yemişçi, Dalkara, Turgay, Elibol, Bülent, Koçak1, Emine Eren |
| Předmět: |
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| Zdroj: |
Anatomy: International Journal of Experimental & Clinical Anatomy; 2020 Supplement, Vol. 14, pS133-S133, 1/3p |
| Abstrakt: |
Objective: It is well known that depressive patients have memory dysfunction. Recent studies showed that there may be differences between males and females in the neurobiological mechanisms and molecules involved in major depression. We aimed to study whether chronic stress affects short- and longterm memory functions differently depending on the sex. Methods: We exposed C57BL/6 female (control n=10, study n=22) and male (control n=6, study n=16) mice to predator, restraint and tail suspension stresses alternately for 35 days. To examine short- and long-term memory, novel object recognition test was performed 1 and 24 hour after the familiarization session. Univariate analysis of variance was used for the statistical analysis. Results: There was a significant difference between female and male mice in short-term memory performance [F(3.54)=6.259 p=0.001], but not in long-term memory performance [F(3.51)= 1.008 p=0.321]. Stress negatively affected both short- and long-term memory performances [F(1.54)=237,549 p=0.008; F(1.51)=23.044 p=0.00000001, respectively]. There was a significant stress X sex interaction on both short- and long-term memory [F(l.54)= 12.297 p=0.007; F(1.51)=4.652 p=0.036 respectively]. Conclusion: While stress affected both short- and long-term memory performances of male mice, it affected only long term memory performance of females. Negative impact of chronic stress on short- and long-term memory performances was more evident in male than female mice. Our results indicate that stress may affect memory functions of male and female mice through different neurobiological mechanisms, which should be investigated by future studies. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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