| Autor: |
Rageh, Eman A., Fahmy, Fahmy E., Alhamshary, Azza A., Mahmoud, Sobhia A., Hassan, Asmaa S. |
| Předmět: |
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| Zdroj: |
Scientific Journal of Al-Azhar Medical Faculty, Girls; Jan-Mar2021, Vol. 5 Issue 1, p34-40, 7p |
| Abstrakt: |
Introduction Vascular endothelial growth factor (VEGF) is a potent proangiogenic factor that acts selectively on endothelial cells, promoting angiogenesis. Angiogenesis plays a critical role in the pathogenesis of inflammatory arthritis, including juvenile idiopathic arthritis (JIA). Power Doppler ultrasonography is a noninvasive valuable technique that provides a reliable image of synovial angiogenesis that helps in evaluation of disease activity. Aim To evaluate serum VEGF in patients with JIA and correlate it with disease activity and ultrasonographic (US) findings and power Doppler of arthritic joints. Patients and methods A total of 50 patients with JIA were subjected to full history taking, clinical examination, routine laboratory investigations, measuring serum VEGF level, and musculoskeletal US examination. Moreover, 25 apparently healthy children were enrolled as controls. Results There was no statistically significant difference regarding serum VEGF between patient and control groups. No statistically significant correlation was found between VEGF and disease activity or US findings in patients with JIA. Conclusion The possible role of VEGF in disease activity of JIA remains unclear and needs further research. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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