| Autor: |
D'Auria, L., Fei, P. Cordiali, Pietravalle, M., Ferraro, C., Mastroianni, A., Bonifati, C., Giacalone, B., Ameglio, F. |
| Předmět: |
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| Zdroj: |
British Journal of Dermatology; Jul1997, Vol. 137 Issue 1, p59-64, 6p |
| Abstrakt: |
Soluble E (sE)-selectin represents the soluble isoform of cellular E-selectin, an adhesion molecule synthesized only by endothelial cells. As a consequence, it may be considered a marker of endothelial activity. The aim of this study was therefore to evaluate the serum levels of sE-selectin in nine patients affected with pemphigus vulgaris (PV) and in 15 patients with bullous pemphigoid (BP). Higher amounts of sE-selectin, median 40.3 ng/mL, range 30–109.6 were found in the patients when compared with 20 healthy individuals, median 28.5 ng/mL, range 6.4–48; P < 0.01, matched for sex and age. These levels were also significantly correlated with the number of detectable lesions (r = 0.63, P < 0001) when the patient data were considered at the time of the first observation. Thirteen subjects were followed over time for a maximum of 3 months (from three to seven observations). During therapy, the number of lesions and the serum sE-selectin values decreased concomitantly. Differently from sE-selectin, the serum soluble intercellular adhesion molecule-1 (sICAM-1) values were not significantly different in the patients from the controls and showed no correlation with the serum sE-selectin concentrations or with the number of lesions. The data presented point to the possible use of sE-selectin determinations as a non-specific follow-up marker, suitable to gauge disease intensity over time and emphasize that endothelial activation is present in BP as well as in PV. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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