| Autor: |
Preethika A., Kumari N., Suchetha, Shetty, Vijith, Shetty, Jayarama, Shetty, Sukanya, Sonkusare, Shipra, Devi, Ullal Harshini, Alva, Priya |
| Předmět: |
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| Zdroj: |
Nitte University Journal of Health Science; 2018 Special Issue, p102-102, 1p |
| Abstrakt: |
Introduction : Breast cancer (BC) is one of the most frequently occurring cancers. Arachidonic acid and its downstream metabolites promote tumorigenesis by supporting processes such as inflammation and angiogenesis, one possibility is that fatty acid metabolism is deregulated in BC patients and may present a new target for cancer treatment. In this study we investigated the fatty acid desaturases activity in women with breast women and control women. Materials and methods: 60 women diagnosed with breast cancer and 40 control women between the age group of 25-60years of age were recruited for this cross-sectional study. The tumors were classified by mode of treatment and estrogen receptor (ER) status .Plasma fatty acid levels were measured by gas chromatographyfame ionisation detector. Fatty acid Desaturases activities(D5, D6 and D9) were estimated as the ratio of product to precursor of individual fatty acids in plasma lipids. Results: Decreased estimates of delta 5 and delta 9 desaturases activity and increased delta 6 desaturase activity were associated with the adverse profile of breast cancer in women than in the control group. Different treatment groups and ER status also showed variation in desaturase activity. Conclusion: These finding shows unbalanced polyunsaturated fatty acids and impaired fatty acid desaturation plays a role in the pathogenesis of breast cancer. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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