| Autor: |
Csincsik, Lajos, Nelson, Rachel, Walpert, Madeleine J., Peto, Tunde, Holland, Anthony, Lengyel, Imre |
| Předmět: |
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| Zdroj: |
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring; 2021, Vol. 13 Issue 1, p1-8, 8p |
| Abstrakt: |
Introduction: People with Down syndrome (DS) are particularly susceptible to Alzheimer’s disease (AD) due to the triplication of the amyloid precursor protein (APP) gene. In this cross-sectional study, we hypothesized that choroidal thinning reported in sporadic AD (sAD) is mirrored in adults with DS. Methods: The posterior pole of the eye for 24 adults with DS and 16 age-matched controls (Ctrl)were imaged with optical coherence tomography. Choroidal thickness (ChT) was measured and analyzed in relation to cognitive status and cerebral amyloid beta (Aβ) load. Results: ChT was increased in people with DS (pwDS) compared to Ctrl. This increase was associated with gender differences and positively correlatedwith cerebral Aβ load in a small subset. There was no significant correlation detected between ChT and age or cognitive status. Discussion: In contrast to sAD this study found a significantly thicker choroid in pwDS. Whether these changes are related to Aβ pathology in DS needs further investigation. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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