| Autor: |
Tucak, Amina, Hindija, Lamija, Hadziabdic, Jasmina, Sirbubalo, Merima, Rahic, Ognjenka, Vranic, Edina |
| Předmět: |
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| Zdroj: |
International Joint Science Congress of Materials & Polymers; 2020, p63-66, 4p |
| Abstrakt: |
Many therapeutic agents have limited utility due to the inability to reach the systemic circulation because of the barrier properties of the biological membranes such as the stratum corneum. Only drugs that have specific physical and chemical properties can be successfully applied transdermally. Microneedles have been developed to try to solve the problem of existing systems because they bypass the stratum corneum and create transient water transport channels of micro dimensions that enhance transdermal permeability. The concept of microneedles has become a subject of significant research in the mid-1990s when the technology of microproduction enabled the development of hollow microneedles for drug infusion into the skin. Today, technology allows integration of microsensors, micropumps, circuits and hollow microneedles into one device, so there is a large number of different devices based on microneedles, which are considered to be more advanced and efficient systems to improve the transport of drug substances. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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