| Abstrakt: |
The present study carried out to determine the histopathological effects for the overdose of (Olanzapine) drug on the liver and kidney of rabbit. The animals wereused eight male rabbits which divided into three groups; low dose treated group (5mg/ml), high dose treated group (10 mg/ml), and control group. It took therapy by oral administration, which was one daily for two weeks and the clinical signs was appear such as depressing, weakness, anorexia. The histopathological change appeared on the examined organs (liver and kidney), which contain of the low treated group, lymphocytes and vaculation, while In the high treated group, the changes were more prominent with hypertrophy hepatocytes large of sinusoid while. Kidney of the both treated group show degeneration cells, necrosis with increased intracellular space in the tubules lumen. The incidences of changes and severity were more in the high dose group. All these results were compared to the control group which don, it appears any structural changes. However, the exposure to the high dose of Olanzapine may be histologically toxic and associated with various pathological conditions such as liver fibrosis and renal dysfunction. [ABSTRACT FROM AUTHOR] |
