| Autor: |
Bahar, Yusra M., Jewad, Abdulkareem M., Al-Mansouri, Loma |
| Předmět: |
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| Zdroj: |
Biochemical & Cellular Archives; Apr2021, Vol. 21 Issue 1, p1119-1123, 5p |
| Abstrakt: |
Recent studies are interested in the effects of breast cancer and chemotherapy combination on blood biomarker. The objective of our study is to determine the effects oxidative stress status represented by measurement of superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR) and malondialdehyde (MDA) in sera of women with breast cancer before and after 2 and 4 cycles of receiving chemotherapy composed of anthracycline, cyclophosphamide and docetaxel (ACD) and comparing them with healthy females. A cohort study used 25 women that diagnosed with breast cancer after surgery and they underwent chemotherapy (ACD), with an age range of (20- 65) years and (25) women with the same age range as a healthy control group. Serum samples of patients were obtained before receiving chemotherapy, after 2 cycles and after 4 cycles of treatment with (ACD). The results showed that the activities of SOD and (GR) and the concentration of MDA were significantly decreased; whereas the activity of (CAT) was unchanged, in serum of women with breast cancer untreated with the chemotherapy (ACD) comparing to the control group. Treating with (ACD) chemotherapy led to opposite the above results. Treating with ACD chemotherapy combination led to overcome the oxidative stress status of the women with breast cancer. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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