Synthesis and antitumor activity of novel pyridoxine-based structural analogs of saccharumoside-B.

Autor:	Pugachev, Mikhail V., Agafonova, Maria N., Bastrikova, Oksana A., Gnezdilov, Oleg I., Nikishova, Tatyana V., Balakin, Konstantin V., Shtyrlin, Yurii G.
Zdroj:	Medicinal Chemistry Research; May2021, Vol. 30 Issue 5, p1139-1150, 12p
Abstrakt:	A series of 11 new pyridoxine-based structural analogs of saccharumoside-B were obtained using original synthetic approach. Antitumor activity of these compounds against nine human tumor cell lines (MCF-7, MDA-MB-231, A-498, SNB-19, M-14, NCI-H322M, HCT-115, HCT-116, and PC-3) was studied, and cytotoxic activity to three normal (HEK-293, Chang Liver, and MSC) cell lines was evaluated. Among the synthesized compounds, 12d, 12e, 13b, 13d, 13e, and 14 exhibited the highest antitumor activity, comparable to that of camptothecin and doxorubicin, but with significantly increased selectivity toward tumor cells. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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