| Autor: |
Rozza-de-Menezes, Rafaela E, Almeida, Lilian M, Andrade-Losso, Raquel M, Vieira, Gustavo de Souza, Siqueira, Orlando H K, Brum, Carolina I, Riccardi, Vincent M, Cunha, Karin S, de Souza Vieira, Gustavo |
| Předmět: |
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| Zdroj: |
American Journal of Clinical Pathology; May2021, Vol. 155 Issue 5, p738-747, 10p |
| Abstrakt: |
Objectives: To evaluate the expression of progesterone receptor (PR), estrogen receptor (ER), and G protein-coupled estrogen receptor 1 (GPER-1) in cutaneous neurofibromas (cNFs) and their correlation with demographic, clinical, and laboratory data of individuals with neurofibromatosis 1 (NF1). The association of PROGINS polymorphism and PR expression in cNFs, as well as the serum steroidal hormones and the number of cNFs, was investigated.Methods: The sample comprised 80 large and 80 small cNFs from 80 individuals with NF1. PR, ER, GPER-1, and Ki-67 expression were investigated by immunohistochemistry in tissue micro- and macroarrays and quantified using a digital computer-assisted method. The number of cNFs, the levels of serum 17β estradiol and progesterone, and the PROGINS polymorphism were identified.Results: Twelve (8.5%) small cNFs were weakly positive for ER, 131 (92.3%) cNFs expressed PR, and all (100%) cNFs expressed GPER-1. Large cNFs showed a higher expression of PR (P < .0001) and GPER-1 (P = .019) and had a higher intensity of staining for these receptors (P < .0001). The cell proliferation index was positively correlated with PR (P = .001). Persons with more cNFs had higher serum levels of progesterone (P = .001).Conclusions: These findings emphasize the role of estrogen and progesterone in cNF development and suggest that these hormones may act on cNF cells via a noncanonical pathway through GPER-1. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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