| Autor: |
Ramesh, D., Kumaraswamy, M. N., Nagarsha, K. M. |
| Předmět: |
|
| Zdroj: |
International Journal of Pharmaceutical, Chemical & Biological Sciences; Jan-Mar2021, Vol. 11 Issue 1, p1-7, 7p |
| Abstrakt: |
The key starting material 8-bromonaphtho [2,1-b]furan-2-carboxyhydrazide 1 was utilized for the synthesis of the title compounds. The carbohydrazide1 was converted into thiosemicarbazide 2a-e by the condensation of appropriate alkyl/arylisothiocyanates These thiosemicarbazides were cyclized using anhydrous phosphoric acid to 5-(8-bromonaphtho[2,1-b]furan-2-yl)-N-alkyl/aryl-1,3,4-thiadiazole-2-amines (3a-e). The thiosemicarbazides 2a-e were cyclized using aqueous sodium hydroxide to 5-(8-bromonaphtho[2,1-b]furan-2-yl-4-sustituted-4H-1,2,4-triazole-3-thiols 3a-e. The structures of newly synthesized compounds have been established by analytical and spectral studies. All the compounds in the series have been screened for their antibacterial and antifungal activities. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
