Clinical features, optical coherence tomography findings and treatment outcomes of post-fever retinitis.
Autor: | M., Dheepak Sundar, Chawla, Rohan, Balaji, Akshaya, Garg, Itika, Kalathil, Reshmi, Hasan, Nasiq, Vikas, S. J., Kumar, Atul |
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Předmět: |
RETINAL disease diagnosis
FEVER RETINA COMBINATION drug therapy STEROIDS ORAL drug administration ENDOTHELIAL growth factors RETROSPECTIVE studies DOXYCYCLINE TREATMENT effectiveness OPTICAL coherence tomography DESCRIPTIVE statistics VISUAL acuity RETINAL diseases EYE examination HEMORRHAGE DRUG administration DRUG dosage SYMPTOMS |
Zdroj: | Therapeutic Advances in Ophthalmology; Jan-Dec2020, Vol. 12, p1-10, 10p, 4 Color Photographs, 2 Charts, 2 Graphs |
Abstrakt: | Objectives: To study the clinical features, optical coherence tomography (OCT) findings, treatment options and follow-up outcomes of post-fever retinitis (PFR). Subjects: A total of 19 eyes of 13 patients, diagnosed with PFR (retinitis following febrile episode) over 2 years were retrospectively studied. Methods: Documented history, baseline clinical features and systemic investigations performed for PFR were reviewed. Fundus findings, foveal architecture on swept-source OCT, the treatment options and the follow-up outcomes including best-corrected visual acuity (BCVA) and central foveal thickness (CFT) were reviewed and analyzed. Results: Common fundus findings included whitish retinitis lesions (100%), macular star (95%, 18eyes), retinal flame-shaped hemorrhages (63%, 12 eyes), inflammatory retinal vessels (30%, 6 eyes), vitreous hemorrhage (one eye) and OCT findings included neuro-sensory detachment (79%, 15 eyes), intraretinal white dots (89.5%,17 eyes). The baseline median log MAR BCVA and CFT were 1.30 (interquartile range (IQR):0.8-1.8) and 423 microns (IQR:182-555). Overall, nine patients (12 eyes) received a combination of oral doxycycline and oral steroids and four patients (7 eyes) received a combination of oral doxycycline, oral steroid and intravitreal anti-vascular endothelial growth factor (IVA). Significant improvement was evident at 8 weeks in median BCVA (0.50, IQR: 0.3-0.8, p < 0.05) and median CFT (223 micron, IQR: 170-256, p < 0.05) though only 26% (5 eyes) attained BCVA > = 6/12. Conclusion: Our study puts forth certain characteristic fundus and OCT features of PFR. A combination of oral doxycycline and oral steroids as a treatment option showed improvement in BCVA and CFT. Additional IVA helps in faster visual recovery in patients presenting with severe macular edema at onset. [ABSTRACT FROM AUTHOR] |
Databáze: | Complementary Index |
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