| Autor: |
Simões, Mônica O. da Silva, Gomes, A. P. B., do Nascimento, T. G., Macêdo, R. O. |
| Předmět: |
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| Zdroj: |
Journal of Thermal Analysis & Calorimetry; 2003, Vol. 72 Issue 2, p539-544, 6p |
| Abstrakt: |
The present study proposes the use of DSC-cooling as a fast tool to evaluate the drug behavior in biofluids submitted to freeze-thaw studies. Captopril, captopril+ascorbic acid and propranolol in plasma were submitted to 3 cycles of freeze-thaw using DSC-cooling up to 243 K. Captopril-plasma has suffered calorimetric alteration and revealed a considerable interaction front to freezing and heating processes. The presence of additive can stabilize the analyte in plasma. Propranolol-plasma presented reducing in phase transition enthalpy comparable to the plasma denatured by perchloric acid in the last cycles of freezing. DSC-cooling data demonstrated great potentiality for the freeze-thaw studies of drugs in biofluids. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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