| Autor: |
Orfanos, Constantin E., Schmidt, Heinz W., Mahrle, Gustav, Gartmann, Heinz, Lever, Walter F. |
| Předmět: |
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| Zdroj: |
British Journal of Dermatology; Feb1973, Vol. 88 Issue 2, p167-182, 16p |
| Abstrakt: |
Topical application of retinoic acid (RA, 0.1 and 0.3% in a cream base) in psoriasis over 3 weeks showed that low therapeutic effect and frequent irritation limit considerably its usefulness in this disease. Of twenty treated patients, six had irritation warranting discontinuation of therapy, thirteen showed improvement, but none cleared completely. However, the therapeutic value was increased and the incidence of irritation was reduced if corticosteroids (CO) were added to RA. Of twenty-four patients treated with RA + CO, eighteen were improved and four cleared completely. Combined treatment seemed also to be more effective than CO alone in the same vehicle. Light and electron microscopic studies after combined treatment showed reappearance of the keratohyaline, disappearance of parakeratosis and acanthosis and improvement of the dilated and fenestrated psoriatic capillaries. However, the number of tonofilaments was still decreased and some dermal changes were still present. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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