| Autor: |
F., Sarpdag, O., Yönem, A., Aktas, Y., Seckin, E., Tuncer, H., Ozer |
| Předmět: |
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| Zdroj: |
Bratislava Medical Journal / Bratislavské Lekárske Listy; 2021, Vol. 122 Issue 5, p331-335, 5p |
| Abstrakt: |
BACKGROUND: Although fi bronectin has an important role in wound repair, nearly no human studies to date have investigated its condition in ulcerative colitis (UC) histologically. E-cadherin plays a critical role in the repair of normal epithelial tissues. This study aims to fi nd out the condition of these two molecules in UC. MATERIAL AND METHODS: The records of 22 UC patients during the period of 2004-2009 were retrospectively analyzed. We also included 24 patients with sporadic colorectal cancer (SCC) and 24 patients with normal colonoscopic biopsies who served as the control group. Colonoscopic biopsies were stained with E-cadherin and fi bronectin. RESULTS: The E-cadherin loss was signifi cantly more prominent in the SCC group, followed by the UC group and control group. The situation was reverse for fi bronectin. We also observed that while the E-cadherin loss was still ongoing in all of the endoscopically inactive cases, the fi bronectin staining resembled the staining pattern of normal individuals in ten out of thirteen UC patients. CONCLUSION: We suggest that the decrease in E-cadherin, even in the inactive period, might be the cause of why UC is not just a compensatory change in repair of infl ammation. The results of staining with fi bronectin in UC patients were between normal individuals and SCC patients. Further studies are necessary to confi rm our results (Tab. 2, Fig. 6, Ref. 15). [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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