| Autor: |
Rigamonti, Andrea, Simonetti, Giorgia, Silvani, Antonio, Rudà, Roberta, Franchino, Federica, Villani, Veronica, Pace, Andrea, Merli, Rossella, Servida, Maura, Picca, Alberto, Berzero, Giulia, Cerase, Alfonso, Chiarotti, Ivano, Spena, Giannantonio, Salmaggi, Andrea |
| Předmět: |
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| Zdroj: |
Neurological Sciences; May2021, Vol. 42 Issue 5, p1879-1886, 8p, 2 Charts, 5 Graphs |
| Abstrakt: |
Background and purpose: Adult brainstem gliomas are rare primary brain tumours with heterogeneous clinical course. The low frequency of these tumours makes it difficult to achieve high-quality evidence regarding prognostic factors, adequate therapeutic approach and outcome in such patients. Methods: In this retrospective study, we analysed clinical, radiological, molecular, prognostic and therapeutic factors in a series of 47 histologically proven adult brainstem gliomas recruited over a 20-year period (1998–2018). Results: Twenty-two patients were male, 25 female with median age of 39 years. The tumour involved one brainstem segment in 20 cases and 2 or more segments in 27. Contrast enhancement was reported in 28 cases. Surgical procedures included biopsy in 26 cases and partial/total resection in the remaining 21. Histological diagnosis was of low-grade glioma in 23 patients, high-grade glioma in 22 and non-diagnostic in 2 cases. Data regarding molecular biology were available for 22 patients. Median overall survival was 35 months, in particular 16 months in high-grade glioma and 84 months in low-grade glioma. At univariate analysis, tumour grade was the only factor with a statistically significant impact on survival time (p = 0,003), whereas younger age, better performance status and total/subtotal resection showed a trend to more prolonged survival. This study also confirms safety of biopsy/surgery in adult brainstem glioma patients and shows a clear trend to a more frequent assessment of molecular biology data. Conclusions: Further prospective multicentre efforts, and hopefully clinical trials, are necessary to improve outcome in this neglected glioma patient population. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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