Oncologic Outcomes of Radical Prostatectomy and High-Dose Intensity-Modulated Radiotherapy with Androgen-Deprivation Therapy for Relatively Young Patients with Unfavorable Intermediate-Risk Prostate Adenocarcinoma.

Autor:	Wu, Szu-Yuan, Chang, Shyh-Chyi, Chen, Chang-I, Huang, Chung-Chien, Kimura, Takahiro, Kimura, Shoji
Předmět:	THERAPEUTIC use of antineoplastic agents ADENOCARCINOMA REPORTING of diseases ANTIANDROGENS MEN'S health CONFIDENCE intervals RADICAL prostatectomy REGRESSION analysis METASTASIS TREATMENT effectiveness COMPARATIVE studies DISEASE relapse RADIATION doses DESCRIPTIVE statistics RADIOTHERAPY COMBINED modality therapy PROSTATE tumors PROPORTIONAL hazards models DISEASE complications ADULTS
Zdroj:	Cancers; Apr2021, Vol. 13 Issue 7, p1517-1517, 1p
Abstrakt:	Simple Summary: Scarce reports have evaluated oncologic outcomes in relatively young men with unfavorable intermediate-risk prostate cancer (UIR-PC) receiving radical prostatectomy (RP) or high-dose intensity-modulated radiotherapy (IMRT). After a literature review, we present the leading and largest head-to-head propensity score-matched study to examine all-cause death, biochemical failure (BF), locoregional recurrence (LRR), and distant metastasis (DM) in relatively young men with UIR-PC undergoing RP or high-dose IMRT. After adjustment for confounders, RP was found to be superior to high-dose IMRT in terms of the patients' overall survival, BF, LRR, and DM. Purpose: To estimate the oncologic outcomes of radical prostatectomy (RP) and high-dose intensity-modulated radiotherapy (IMRT) with short-term androgen-deprivation therapy (ADT) in relatively young men with unfavorable intermediate-risk prostate cancer, as defined by the National Comprehensive Cancer Network (NCCN-UIR-PC). Patients and Methods: We enrolled relatively young men (≤65 years) from the Taiwan Cancer Registry who had been diagnosed as having NCCN-UIR-PC and who had received RP or high-dose IMRT (at least ≥72 Gy) with short-term ADT (4–6 months). After propensity score matching of the confounders, Cox proportional regression was used to model the time from the index date (i.e., date of diagnosis) to all-cause death, biochemical failure (BF), locoregional recurrence (LRR), and distant metastasis (DM). Results: The corresponding adjusted hazard ratios (95% confidence intervals) of the risk of all-cause death, BF, LRR, and DM were 2.76 (1.36–5.60, p = 0.0050), 2.74 (1.72–4.84, p < 0.0001), 1.28 (1.09–1.90, p = 0.0324), and 2.11 (1.40–4.88, p = 0.0052), respectively. Conclusions: RP is superior to high-dose IMRT with short-term ADT in terms of oncologic outcomes for relatively young men with UIR-PC. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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