Synthesis and Cytotoxic Activity of 5α-Pregnanolone Hydrazones.

Autor:	Nadaraia, N. Sh., Kakhabrishvili, M. L., Barbakadze, N. N., Mshvildadze, V. D., Mulkidzhanyan, K. G., Pichette, A.
Předmět:	HYDRAZONES HYDRAZONE derivatives CATALYTIC hydrogenation MASS spectrometry STRUCTURE-activity relationships ISONICOTINIC acid
Zdroj:	Chemistry of Natural Compounds; Mar2021, Vol. 57 Issue 2, p395-397, 3p
Abstrakt:	SP 13 sp C NMR spectra of hydrazones B 2 b - B 6 b showed C-3 resonances at 70.4-69.6 ppm; aromatic C atoms, 154.9-111.1; C=N bonds, 164.7-152.0. In continuation of work on a structure-activity relationship [[7]], 5 -pregnan-3 -ol-20-one ( B 1 b ) was used to synthesize new B 2 b - B 6 b and known hydrazones B 7 b and B 8 b [[4]]. Aromatic protons had chemical shifts (CS) in the range 9.10-6.97 ppm; hydrazone NH of B 2 b and B 3 b , 7.71 and 11.05; NHCO protons of B 4 b - B 6 b , 10.95-10.55. [Extracted from the article]
Databáze:	Complementary Index
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