Bromodomain‐containing protein 4 and its role in cardiovascular diseases.

Autor: Li, Liang, Xie, Wei, Gui, Yu, Zheng, Xi‐Long
Předmět:
Zdroj: Journal of Cellular Physiology; Jul2021, Vol. 236 Issue 7, p4829-4840, 12p
Abstrakt: Bromodomain‐containing protein 4 (BRD4), a chromatin‐binding protein, is involved in the development of various tumors. Recent evidence suggests that BRD4 also plays a significant role in cardiovascular diseases, such as ischemic heart disease, hypertension, and cardiac hypertrophy. This review summarizes the roles of BRD4 as a potential regulator of various pathophysiological processes in cardiovascular diseases, implicating that BRD4 may be a new therapeutic target for cardiovascular diseases in the future. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index