Of Mice and Men: Impacts of Calorie Restriction on Metabolomics of the Cerebellum.

Autor:	García-Flores, Libia Alejandra, Green, Cara L
Předmět:	LOW-calorie diet CEREBELLUM METABOLOMICS MICE NEUROANATOMY BIOLOGICAL models BIOCHEMISTRY RESEARCH NEURAL pathways ANIMAL experimentation RESEARCH methodology METABOLISM INGESTION MEDICAL cooperation EVALUATION research DIET therapy COMPARATIVE studies HYPOTHALAMUS LONGEVITY
Zdroj:	Journals of Gerontology Series A: Biological Sciences & Medical Sciences; Apr2021, Vol. 76 Issue 4, p547-551, 5p
Abstrakt:	The main purpose of research in mice is to explore metabolic changes in animal models and then predict or propose potential translational benefits in humans. Although some researchers in the brain research field have mentioned that the mouse experiments results still lack the complex neuroanatomy of humans, caution is required to interpret the findings. In mice, we observed in article seventeenth of the series of the effects of graded levels of calorie restriction, metabolomic changes in the cerebellum indicated activation of hypothalamocerebellar connections driven by hunger responses. Therefore, the purpose of the current perspective is to set this latest paper into a wider context of the physiological, behavioral, and molecular changes seen in these mice and to compare and contrast them with previous human studies. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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