| Autor: |
Dau, Tran Anh Nguyet, Le, Van Manh Hung, Pham, Thi Kim Hong, Le, Van Hieu, Cho, Somi Kim, Nguyen, Thai Ngoc Uyen, Ta, Thi Kieu Hanh, Van Tran, Thi Thanh |
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| Zdroj: |
Journal of Electronic Materials; May2021, Vol. 50 Issue 5, p2932-2939, 8p |
| Abstrakt: |
In this study, MCM-41 mesoporous silica nanoparticles were successfully synthesized by the condensation of a tetraorthosilicate precursor on a template self-assembled by cetyltrimethylammonium bromide in alkaline. The small-angle x-ray diffraction patterns of MCM-41 indicate that silica nanoparticles possess hexagonal structures with a high degree of structural ordering. Transmission electron microscopy images show that the size of the MCM-41 particles is around 100-120 nm, and the pore sizes range from 2 nm to 4 nm. In addition, the specific surface area of MCM-41 obtained by Brunauer–Emmett–Teller analysis is as high as 987 m2.g−1 and the pore size extracted from nitrogen physical adsorption isotherms is in accordance with the TEM result. Thermogravimetric analysis, Fourier-transform infrared spectroscopy, Zeta potential measurements and photoluminescence measurements show that 3-aminopropyltriethoxysilane (APTES) and doxorubicin were grafted and loaded successfully onto MCM-41 nanoparticles. An assay on fibroblasts, A549 and doxorubicin-resistant A549/DOX cells indicates that the prepared MCM41 grafting APTES nanoparticles are safe to normal cells and toxic to cancer cells in vitro. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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