Autor: |
Wang, Tanzhen, Zhou, Biqi, Zhang, Jubin, Zhang, Xinyue, Liu, Tianhui, Qiu, Huiying, Sun, Aining, Chen, Suning, Wu, Depei, Xu, Yang |
Předmět: |
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Zdroj: |
Leukemia & Lymphoma; Apr2021, Vol. 62 Issue 4, p995-998, 4p |
Abstrakt: |
The role of MRD-directed risk stratification strategy for core binding factor acute myeloid leukemia (CBF-AML) patients with favorable risk genetics is still unknown. We retrospectively analyzed the clinical outcomes of 148 pure CBF-AML patients with first complete remission including MRD positive (n = 69) and MRD negative (n = 79) after two courses of consolidation from January 2009 to December 2018 in our center. We found that MRD positive after 2 courses of consolidation significantly influenced OS (5-year: 59%), PFS (5-year: 36%) and CIR (5-year: 58%) in favorable-risk CBF-AML patients with CR1. It was worth noting that the MRD status after two courses of consolidation might be the best timing for treatment choice and allo-HSCT was a promising treatment for favorable-risk CBF-AML patients with MRD positive after the second consolidation. [ABSTRACT FROM AUTHOR] |
Databáze: |
Complementary Index |
Externí odkaz: |
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