| Autor: |
Nogues, Perrine, Dos Santos, Esther, Couturier-Tarrade, Anne, Berveiller, Paul, Arnould, Lucie, Lamy, Elodie, Grassin-Delyle, Stanislas, Vialard, François, Dieudonne, Marie-Noëlle |
| Předmět: |
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| Zdroj: |
Journal of Clinical Endocrinology & Metabolism; Apr2021, Vol. 106 Issue 4, pe1880-e1896, 17p |
| Abstrakt: |
Context: Maternal obesity has a significant impact on placental development. However, this impact on the placenta's structure and function (ie, nutrient transport and hormone and cytokine production) is a controversial subject.Objective: We hypothesized that maternal obesity is associated with morphologic, secretory, and nutrient-related changes and elevated levels of inflammation in the placenta.Design: We collected samples of placental tissue from 2 well-defined groups of pregnant women from 2017 to 2019. We compared the 2 groups regarding placental cytokine and hormone secretion, immune cell content, morphology, and placental nutrient transporter expressions.Setting: Placenta were collected after caesarean section performed by experienced clinicians at Centre Hospitalier Intercommunal (CHI) of Poissy-Saint-Germain-en-Laye.Patients: The main inclusion criteria were an age between 27 and 37 years old, no complications of pregnancy, and a first-trimester body mass index of 18-25 kg/m2 for the nonobese (control) group and 30-40 kg/m2 for the obese group.Results: In contrast to our starting hypothesis, we observed that maternal obesity was associated with (1) lower placental IL-6 expression and macrophage/leukocyte infiltration, (2) lower placental expression of GLUT1 and SNAT1-2, (3) a lower placental vessel density, and (4) lower levels of placental leptin and human chorionic gonadotropin production.Conclusion: These results suggest that the placenta is a plastic organ and could optimize fetal growth. A better understanding of placental adaptation is required because these changes may partly determine the fetal outcome in cases of maternal obesity. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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