Biodistribution of iron-oxide-stabilized 99mTc- ZrO2 nanoparticles in rabbit using honey as a capping agent—microwave-assisted sol–gel approach.

Autor: Imran, M., Riaz, Saira, Batool, Tanzeela, Qamar, Amreen, Khan, Irfan Ullah, Zahoor, Rizwana, Shahid, Abubaker, Naseem, Shahzad
Zdroj: Journal of Sol-Gel Science & Technology; Apr2021, Vol. 98 Issue 1, p95-112, 18p
Abstrakt: One of the major biomedical problems facing worldwide is the diagnosis and treatment of tumor. This disease may lead to severe incidence with increased mortality rates. Therefore, it is the need of present era to develop advanced tools/methods for timely diagnosis of tumor. Aim of the present study is to evaluate the cytotoxicity and biodistribution of iron-oxide-stabilized zirconia (IOZH) nanoparticles with honey as a capping agent. In vivo-targeted diagnostic applications of stabilized ZrO2 nanoparticles are investigated through biodistribution of nanoparticles in rabbits. Nanoparticles (NPs) are synthesized using the microwave-assisted sol–gel method. Powers of microwave energy (100–900 W) are varied to synthesize stabilized zirconia NPs. Honey, as an organic capping agent, is added during synthesis. Structural results demonstrate the appearance of stabilized tetragonal phase of zirconia at 700 and 900 W without any further heat treatments. Smaller crystallite size of ~20 nm is observed for stabilized zirconia samples. Higher X-ray density is observed for pure tetragonal phase at 700 and 900 W. High dielectric constant (~55.8 at log f = 4) along with low tan loss is observed for zirconia prepared at 900 W. Magnetic results show superparamagnetic nature of the samples synthesized at 700 and 900 W. Radiolabeling along with biodistribution of iron-oxide-stabilized zirconia nanoparticles with technetium-99m is studied in normal rabbits. It is worth mentioning here that high-yield efficacy and stability along with its biodistribution and scintigraphy studies have been investigated. High uptake of radiotracer in bladder of rabbit is found to be potential candidate for its use in tumor therapies. Urination and physical properties of rabbit, after the post injection of nanoparticles, are checked periodically for many months and found normal. Highlights: Iron-oxide-stabilized zirconia (IOZH) nanoparticles, with honey as capping agent, were synthesized using the microwave-assisted sol–gel method. Powers of microwave (100–900 W) were varied to synthesize nanoparticles. XRD results showed the appearance of stabilized tetragonal phase of zirconia at 700 and 900 W without any further heat treatments. High dielectric constant (~55.8 at log f = 4) along with low tangent loss was observed for samples prepared at 900 W. Magnetic results showed superparamagnetic nature of the samples synthesized at 700 and 900 W. Radiolabeling along with biodistribution of iron-oxide-stabilized zirconia nanoparticles with technetium-99m was studied in normal rabbits. High uptake of radiotracer in bladder of rabbit was found to be strong candidate for its use in tumor therapies. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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