| Autor: |
Betti, Marta, Bertolotti, Marinella, Ferrante, Daniela, Roveta, Annalisa, Pelazza, Carolina, Giacchero, Fabio, Penpa, Serena, Massarino, Costanza, Bolgeo, Tatiana, Cassinari, Antonella, Mussa, Marco, Chichino, Guido, Maconi, Antonio |
| Předmět: |
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| Zdroj: |
PLoS ONE; 3/24/2021, Vol. 16 Issue 3, p1-10, 10p |
| Abstrakt: |
Background: Individual differences in susceptibility to SARS-CoV-2 infection, symptomatology and clinical manifestation of COVID-19 have thus far been observed but little is known about the prognostic factors of young patients. Methods: A retrospective observational study was conducted on 171 patients aged ≤ 65 years hospitalized in Alessandria's Hospital from 1st March to 30th April 2020 with laboratory confirmed COVID-19. Epidemiological data, symptoms at onset, clinical manifestations, Charlson Comorbidity Index, laboratory parameters, radiological findings and complications were considered. Patients were divided into two groups on the basis of COVID-19 severity. Multivariable logistic regression analysis was used to establish factors associated with the development of a moderate or severe disease. Findings: A total of 171 patients (89 with mild/moderate disease, 82 with severe/critical disease), of which 61% males and a mean age (± SD) of 53.6 (± 9.7) were included. The multivariable logistic model identified age (50–65 vs 18–49; OR = 3.23 CI95% 1.42–7.37), platelet count (per 100 units of increase OR = 0.61 CI95% 0.42–0.89), c-reactive protein (CPR) (per unit of increase OR = 1.12 CI95% 1.06–1.20) as risk factors for severe or critical disease. The multivariable logistic model showed a good discriminating capacity with a C-index value of 0.76. Interpretation: Patients aged ≥ 50 years with low platelet count and high CRP are more likely to develop severe or critical illness. These findings might contribute to improved clinical management. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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