Three-Component Condencations of 3-Amino-1,2,4-triazoles, Methyl 3-(2-Cycloamino-4-methylpyrimidin-5-yl)-3-oxopropionoates, and a Series of C1 Synthons as a Convenient Approach to Pyrimidin-5-yl-1,2,4-triazolo[1,5-a]pyrimidines.

Autor:	Potapov, A. Yu., Polikarchuk, V. A., Paponov, B. V., Ledeneva, I. V., Stolpovskaya, N. V., Kryl'skii, D. V., Shikhaliev, Kh. S.
Předmět:	PYRIMIDINE derivatives AROMATIC aldehydes MOLECULAR hybridization CONDENSATION MOIETIES (Chemistry)
Zdroj:	Russian Journal of Organic Chemistry; Feb2021, Vol. 57 Issue 2, p219-225, 7p
Abstrakt:	A convenient synthetic approach to polysubstituted dihydrogenated or heteroaromatic 1,2,4-triazolo[1,5-a]pyrimidines derivatives containing at position 5 a 4-methylpyrimidine moiety bearing a cycloamino substituent at position 2 and linked to the triazolopyrimidine bicycle through its position 5 was developed. The approach involves unusual three-component condensations of 3-amino-1,2,4-triazoles, methyl 3-(2-R-4-methylpyrimidin-5-yl)-3-oxopropionates, and a series of C1 synthons whose synthetic equivalents are a series of aromatic aldehydes, triethyl orthoformate, or DMFDMA were used as of C1 synthons. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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