Design, Synthesis, and Anti-Breast Cancer Activity of Some Hybrid Molecules Containing Coumarin Moiety.

Autor:	Eman M. Radwan, Elsayed, Elsherbiny H., El-Moneim, Mohamed Abd, Moustafa, Amal M. Youssef
Předmět:	COUMARINS MOIETIES (Chemistry) ACETIC acid MOLECULES ACETIC anhydride BREAST cancer
Zdroj:	Russian Journal of Bioorganic Chemistry; Jan2021, Vol. 47 Issue 1, p149-157, 9p
Abstrakt:	(Benzimidazol-2-yl)-7-hydroxycoumarin and N-(2-hydroxyphenyl)-7-hydroxycoumarin-3-carboxamide have been synthesized by the condensation of ethyl 7-hydroxycoumarin-3-carboxylate in acetic acid. Acetylation with acetic anhydride and halogenation with bromine in acetic acid's presence of the previous compounds has yielded the corresponding acetoxy and dibromo derivatives. The synthesized molecules that contain coumarin ring have been evaluated for their activities against breast cancer and they have shown good in vitro antiproliferative activities against a human breast cancer line (MCF-7). The results have shown that 3-(benzimidazol-2-yl)-7-acetoxycoumarin had a significant cytotoxic effect compared to the standard DOX (doxorubicin) drug. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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