| Autor: |
Guilherme, João Paulo Limongi França, Semenova, Ekaterina A., Zempo, Hirofumi, Martins, Gabriel L., Lancha Junior, Antonio H., Miyamoto-Mikami, Eri, Kumagai, Hiroshi, Tobina, Takuro, Shiose, Keisuke, Kakigi, Ryo, Tsuzuki, Takamasa, Ichinoseki-Sekine, Noriko, Kobayashi, Hiroyuki, Naito, Hisashi, Borisov, Oleg V., Kostryukova, Elena S., Kulemin, Nikolay A., Larin, Andrey K., Generozov, Edward V., Fuku, Noriyuki |
| Předmět: |
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| Zdroj: |
International Journal of Sports Physiology & Performance; Apr2021, Vol. 16 Issue 4, p489-495, 7p, 3 Charts, 1 Graph |
| Abstrakt: |
Purpose: To replicate previous genome-wide association study identified sprint-related polymorphisms in 3 different cohorts of top-level sprinters and to further validate the obtained results in functional studies. Methods: A total of 240 Japanese, 290 Russians, and 593 Brazilians were evaluated in a case-control approach. Of these, 267 were top-level sprint/power athletes. In addition, the relationship between selected polymorphisms and muscle fiber composition was evaluated in 203 Japanese and 287 Finnish individuals. Results: The G allele of the rs3213537 polymorphism was overrepresented in Japanese (odds ratio [OR]: 2.07, P =.024) and Russian (OR: 1.93, P =.027) sprinters compared with endurance athletes and was associated with an increased proportion of fast-twitch muscle fibers in Japanese (P =.02) and Finnish (P =.041) individuals. A meta-analysis of the data from 4 athlete cohorts confirmed that the presence of the G/G genotype rather than the G/A+A/A genotypes increased the OR of being a sprinter compared with controls (OR: 1.49, P =.01), endurance athletes (OR: 1.79, P =.001), or controls + endurance athletes (OR: 1.58, P =.002). Furthermore, male sprinters with the G/G genotype were found to have significantly faster personal times in the 100-m dash than those with G/A+A/A genotypes (10.50 [0.26] vs 10.76 [0.31], P =.014). Conclusion: The rs3213537 polymorphism found in the CPNE5 gene was identified as a highly replicable variant associated with sprinting ability and the increased proportion of fast-twitch muscle fibers, in which the homozygous genotype for the major allele (ie, the G/G genotype) is preferable for performance. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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