Clinical Evaluation of Proline, Glutamic acid, and Leucine-Rich Protein 1 Expression in Astrocytomas and Correlations with the Proliferation Marker Ki-67.

Autor: Padmavathy, Karthika P., Vuttaradhi, Veena Kumari, Venu, Akkanapally, D'Cruze, Lawrence, Saravanan, Roshni, Pitani, Ravishankar, Ganesh, Krishnamurthy, Pacharla, Himavani, Rayala, Suresh Kumar, Prathiba, D., Venkatraman, Ganesh
Zdroj: Journal of Molecular Neuroscience; Apr2021, Vol. 71 Issue 4, p724-733, 10p
Abstrakt: Malignant astrocytomas presenting in humans of any age group are a challenge to diagnose and treat. Hence, there is a quest for new markers to ascertain their grades and predict disease outcomes. Proline, glutamic acid, and leucine-rich protein 1 (PELP1), a nuclear receptor co-regulator, is an oncogene found in various cancers. We postulate that by screening for PELP1, its correlation with survival outcomes of patients across various grades can indicate a plausible novel diagnostic marker and a potential therapeutic target in gliomas. Immunostaining of 100 cases of astrocytomas for PELP1 was performed on paraffin-embedded sections. Results showed that PELP1 expression increases with higher grades; the mean H-score of PELP1 in grade-I astrocytomas was determined to be 112.3, whereas in grade-IV it was 235.1 (P value = 0.0001). Survival analysis of patients with H-score of 200–300 was only 8.8% and 68.8% in patients with scores of 0–100. PELP1 expression in high-grade astrocytomas is an important factor in determining the outcomes. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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