| Autor: |
SARMA, Gautam, BORAH, Luri, NATH, Jyotiman, BHATTACHARYYA, Mouchumee, MEDHI, Partha Pratim, KALITA, Apurba Kumar |
| Předmět: |
|
| Zdroj: |
Turkish Journal of Oncology / Türk Onkoloji Dergisi; 2021, Vol. 36 Issue 1, p61-70, 10p |
| Abstrakt: |
OBJECTIVE The incidence of cervical cancer among older women is increasing. The treatment outcome in these patients is affected byvarious patient and tumor-related factors. In this study, we retrospectively investigated the survival outcomes, treatment-related toxicity, and patterns of failures for elderly patients (≥75 years old) with cervical cancer treated with definitive radiotherapy. METHODS Twenty-three patient's fulfilling inclusion and exclusion criteria were analyzed. The survival was studied using the Kaplan-Meir method, and its relation with different clinicopathologic parameters was compared. RESULTS After a median follow-up time of 46 months (range 3-93), the overall survival for the entire cohort of patients at 5 years and 7 years were 54.9% and 43.9%, respectively, and the disease-free survival at 3 years and 5 years were 66.3% and 45.9% respectively. Patients receiving total radiation dose (EqD2) more than 80 Gy achieved statistically significant improved survival than those receiving lower doses (p=0.04). Grade 111 acute toxicity was experienced by 2 patients (8.7%) with diarrhea and one patient (4.3%) with dermatitis, but no grade 1V acute toxicity was recorded. Two patients (8.7%) developed rectal bleeding as late toxicity. At the end of follow-up, 11 patients (47.8%) experienced a relapse. Distant metastasis to the lung was the most common type of failure. CONCLUSION Definitive radiotherapy is safe and well-tolerated by elderly patients with cervix cancer with an acceptable degree of toxicities. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
|
