| Autor: |
Mohan, Mitali, Batty, Kevin T., Cooper, Jennifer A., Wojnar-Horton, Richard E., Ilett, Kenneth F. |
| Předmět: |
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| Zdroj: |
British Journal of Clinical Pharmacology; Nov2004, Vol. 58 Issue 5, p521-527, 7p |
| Abstrakt: |
To compare gentamicin dose estimates from four predictive methods.A retrospective study was conducted, comprising patients at Fremantle Hospital who received gentamicin therapy and had at least one gentamicin serum concentration reported. A manual calculation method, the Australian‘Therapeutic Guidelines: Antibiotic’ (TGA) nomogram and the SeBA-GEN and DoseCalc software packages were compared. SeBA-GEN dose estimates were regarded as the reference standard.There were 64 males and 30 females with mean age of 58 ± 16 years. In patients with moderate renal impairment (CLCr = 30–60 ml min−1;n = 21), mean dose estimates using DoseCalc and the manual calculation method were comparable to SeBA-GEN but the mean TGA nomogram dose (230 mg; 95% confidence interval 179, 281) was significantly lower than SeBA-GEN (286 mg; 261, 311;P = 0.002; one-way RManova). In patients with mild renal impairment (CLCr = 60–90 ml min−1;n = 48), DoseCalc (392 mg; 367, 427) was comparable to SeBA-GEN (377 mg; 362, 392). Although the manual method (341 mg; 306, 376;P = 0.007) and the TGA nomogram (335 mg; 302, 368;P < 0.001) estimates were significantly lower than SeBA-GEN, the practical difference was modest.SeBA-GEN and DoseCalc are generally comparable for estimation of gentamicin doses in patients with renal impairment. The‘Therapeutic Guidelines: Antibiotic’ nomogram is a valid approach to dosage estimation, but only when used in patients with normal renal function. Simple manual calculations are a suitable alternative in patients with renal impairment. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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