Incidental Papillary Thyroid Carcinoma in Primary Hyperparathyroidism with False Negative Sestamibi Scan: A Challenging Surgical Exploration and Diagnosis.

Autor: Zahari, Azihan, Yahya, Maya Mazuwin, Nawi, Norazlina Mat, Baba, Farahlina, Rahman, Wan Faiziah Wan Abdul
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Zdroj: Surgical Chronicles; Oct-Dec2020, Vol. 25 Issue 4, p384-387, 4p
Abstrakt: The coexistence of primary hyperparathyroidism (PHPT) and non-medullary differentiated thyroid carcinoma (NMTC) is rare but it does happen. The possibility of thyroid cancer should be considered in cases of primary hyperparathyroidism with coexistent thyroid nodules. The clinical diagnosis and treatment is quite challenging when sestamibi scan is negative that will lead to second surgery and exposing the patients to morbidity. There are multiple opinions regarding the role of investigating thyroid lesions in primary hyperparathyroidism patients. Multiple imaging modalities are used for preoperative localization of parathyroid lesion, including ultrasonography (USG), sestamibi scintigraphy SPECT/CT, and four-dimensional computed tomography (4D-CT) with different sensitivity and specificity. These various imaging techniques are meant for localization of nodular parathyroid lesions to reduce the need for unnecessary exploration by targeting the focal lesion approach. Sestamibi scintigraphy SPECT/CT is usually recommended as an investigation of choice. However, ultrasound acts as the perfect diagnostic tool to detect concomitant thyroid and parathyroid nodules because it is an inexpensive and non-invasive technique. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index