| Abstrakt: |
Introduction. Arsenic is one of the most toxic elements, discovered on the Earth, and poses a very serious threat to human health and life. Aim of the work – assessment of risk to the population health of the natural area in the eastern part of Russia, caused by the use of drinking water containing arsenic. Materials and Methods. The population of one of the provinces of Eastern Siberia, characterized by an increased content of arsenic in water (147 people) was examined. Examination included: determination of As content in water and products, in blood of examined persons by the mass spectrometry method (ICP-MS4); laboratory research (hematological, biochemical, enzyme immunoassay) completed with the help of automatic analyzer («АcТ5diff AL», «Keylab», «Infinite F50»); clinical and functional examination in compliance with ethical standards; population health risks in accordance with Р 2.1.10.1920-04; analysis of represented medical documentation; statistical analysis of results obtained. Results. Analysis of drinking water quality, supplied by centralized Water Supply system, in the studied settlement revealed the presence of As, with an excess of the element content (0.002 - 4.3 mg / dm³) up to 86 maximum allowable concentrations (MAC). Analysis of biological samples individual indicators revealed excess arsenic content in blood serum of 8% of adults (0.0171 mg / l - 0.0636 mg / l) and 19% of children (0.0162 mg / l - 0.0377 mg / l). The results of the survey showed that as a result of the consumption of drinking water with an increased content of arsenic (from wells 100-120 m deep), severe harm to health was caused in 44% of cases (malignant neoplasms, damage to the peripheral nervous system), in 46% - medium (arsenic dyschromia). Mild health damage was caused in 9.3% (autonomic dysfunction). Assessment of lifelong carcinogenic risk, due to consumption of drinking water with the high content of Arsenic, showed unacceptable level in the observation group for the adult population (4.09 × 10-2) and for children (1.91 × 10-2). Conclusion. The content of 2.5 mg / dm3 of arsenic in the water of wells 100 meters deep and more contributes to the formation of an unacceptable level of carcinogenic (up to 4.1 × 10-2) and non-carcinogenic (HQ up to 494) risks to public health. Realization of the risk in conditions of drinking water consumption with an As content exceeding 50 MAC is manifested by the development of oncological pathologies of various localization in the adult population; an unacceptable non-carcinogenic risk of developing effects is also formed, which is manifested by the development of diseases of the peripheral nervous system and circulatory system. [ABSTRACT FROM AUTHOR] |
