| Autor: |
Pachaiyappan, Abirami, Sadhasivam, Giji, Kumar, Mohan, Muthuvel, Arumugam |
| Zdroj: |
Waste & Biomass Valorization; Apr2021, Vol. 12 Issue 4, p2119-2129, 11p |
| Abstrakt: |
Pigments plays important role in the biological functions of animals but not all of them could obtain it only through diet especially those thrive in aquatic environment. Hence, these marine organisms live in symbiotic association with microbes (endosymbiotic) that could serve as an alternative source for the biosynthesis of many unique metabolites with characteristic therapeutic uses. Taking this in consideration the current investigation was focused to identify and study the biological properties of pigment from marine endophytic bacteria associated with the bivalve, Donax cuneatus. Totally, three strains were characterized and identified the type of carotenoid present using HPTLC and HPLC. Further tested for its cytotoxic effect on human breast cancer cell line (MCF-7) at different sub-lethal concentrations ranging from 100 to 6.25 µg/ml. The pigments isolated from the strains were found to possess significant antibacterial and free radical scavenging properties. The pigment present was identified as astaxanthin in the strain OP2 was purified in chromatography exhibited pronounced cytotoxic effect on MCF-7. The three strains were identified using 16SrRNA gene sequencing. Therefore, the diverse relationships existing between organism and their guest's microorganisms provoke that the active compounds can eventually be used as a source of new leads for betterment of human welfare. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
| Externí odkaz: |
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