Comparison of Inflammation-Based Prognostic Scores Associated with the Prognostic Impact of Adenocarcinoma of Esophagogastric Junction and Upper Gastric Cancer.

Autor: Kudou, Kensuke, Nakashima, Yuichiro, Haruta, Yasuhiro, Nambara, Sho, Tsuda, Yasuo, Kusumoto, Eiji, Ando, Koji, Kimura, Yasue, Hashimoto, Kenkichi, Yoshinaga, Keiji, Saeki, Hiroshi, Oki, Eiji, Sakaguchi, Yoshihisa, Kusumoto, Tetsuya, Ikejiri, Koji, Shimokawa, Mototsugu, Mori, Masaki
Zdroj: Annals of Surgical Oncology: An Oncology Journal for Surgeons; Apr2021, Vol. 28 Issue 4, p2059-2067, 9p
Abstrakt: Background: Several inflammation-based prognostic scores have a prognostic value in patients with various cancers. This study investigated the prognostic value of various inflammation-based prognostic scores in patients who underwent a surgery for adenocarcinoma of the esophagogastric junction (AEG) and upper gastric cancer (UGC). Methods: We reviewed data of 206 patients who underwent surgery for AEG and UGC. We calculated neutrophil–lymphocyte ratio (NLR), platelet–lymphocyte ratio (PLR), Glasgow Prognostic Score (GPS), modified GPS (mGPS), C-reactive protein (CRP)/albumin (Alb) ratio, prognostic index (PI), and prognostic nutritional index (PNI) and analyzed the relationship between these biomarkers and postoperative prognosis. Results: In multivariate analyses for overall survival, mGPS (P = 0.0337, hazard ratio [HR] = 5.211), PI (P = 0.0002, HR = 21.20), and PNI (P < 0.0001, HR = 6.907) were identified as independent predictive factors. A multivariate analysis for recurrence-free survival showed that only PI (P = 0.0006, HR = 11.89) and PNI (P = 0.0002, HR = 4.972) were independent predictive factors among the above-mentioned inflammation-based prognostic scores. Conclusions: In various inflammation-based prognostic scores, PI and PNI were more strongly associated with poor prognosis in patients who underwent surgery for AEG and UGC. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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