Sister chromatid exchange and chromosome aberration rates in a group of psoriatics before and after a course of PUVA treatment.

Autor:	Faed, M. J. W., Williamson, L., Peterson, S., Lakshmipathi, T., Johnson, B. E., Frain-Bell, W.
Předmět:	SISTER chromatid exchange CHROMOSOMES CHROMOSOME replication PHOTOCHEMOTHERAPY SKIN diseases DERMATOLOGY
Zdroj:	British Journal of Dermatology; Sep1980, Vol. 103 Issue 3, p295-299, 5p
Abstrakt:	Blood was cultured and chromosome preparations were examined for sister chromatid exchanges and chromosome aberrations in eighteen patients receiving photochemotherapy with 8-MOP and UV-A for the treatment of psoriasis, both before starting treatment and again 6 months later. The UV-A was administered both by means of low output (irradiance: 1.1–2.25 mW/cm2) and high output (irradiance: 6.1–7.6 mW/cm2) UV-A radiation cubicles. Irrespective of the intensity of irradiation or the total dose of UV-A administered there was no evidence of chromosome damage in lymphocytes following treatment. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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