| Autor: |
Clementsen, P., Milman, N., Struve-Christensen, E., Petersen, B. Nüchel, Pedersen, M., Bisgaard, H., Permin, H., Norn, S. |
| Předmět: |
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| Zdroj: |
Allergy; Jan1991, Vol. 46 Issue 1, p45-51, 7p |
| Abstrakt: |
Histamine release induced by Staphylucoccus aureus was examined in cells obtained by bronchoalveolar lavage (BAL) in non-atopic mdividuals. Approximately half of the individuals responded with mediator release to the bacterium, and the release was found to be time- and concentration dependent. No difference was found between the patients who responded and those who did not respond in regard to age, sex, smoker/non smoker, % recovery of BAL-fluid, total cell count, differential cell counts, histamine content per mast cell, or diagnoses. Also stimulation of the BAL-cells with the calcium-ionophore A23187 resulted in histamine release, S. aureus-induced histamine release from basophil was examined in leukocyte suspensions obtained from the same individuals, and in all experiments release was found. The dose-response curves were similar to those obtained with BAL cells- The bacteria-induced mediator release from superficially lying cells in the airways epithelium might be of importance for the precipitation or exacerbation of bronchial asthma in respiratory tract infections. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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