| Autor: |
Waard, Antonius A., Verkerk, Tamara, Jongsma, Marlieke L. M., Hoefakker, Kelly, Sethumadhavan, Sunesh, Gerke, Carolin, Bliss, Sophie, Kong, Xiangrui, Janssen, George M. C., Ru, Arnoud H., Claas, Frans H. J., Mulder, Arend, Tampé, Robert, Veelen, Peter A., Halenius, Anne, Spaapen, Robbert M. |
| Předmět: |
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| Zdroj: |
European Journal of Immunology; Mar2021, Vol. 51 Issue 3, p734-737, 4p |
| Abstrakt: |
These cells have a common HLA-I haplotype (A*02:01, B*40:01, C*03:04), a functional HLA-I antigen presentation pathway, an excellent cloning capacity, and a high proliferation rate. Keywords: APM; antigen presentation; HLA class I; CRISPR/Cas9; MHC EN APM antigen presentation HLA class I CRISPR/Cas9 MHC 734 737 4 03/05/21 20210301 NES 210301 A single model system for integrative studies on multiple facets of antigen presentation is lacking. The understanding of HLA-I antigen processing and presentation is more relevant than ever due to commonly occurring HLA-I-mediated resistance after cancer immunotherapy [4]. Unsupervised sequence clusters generated from the 9-mer peptides were in concordance with reported logos for HLA-A*02:01, HLA-B*40:01, and HLA-C*03:04 (Fig. [Extracted from the article] |
| Databáze: |
Complementary Index |
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