Inflammation markers on benign breast biopsy are associated with risk of invasive breast cancer in African American women.

Autor: Shaik, Asra N., Kiavash, Katrin, Stark, Karri, Boerner, Julie L., Ruterbusch, Julie J., Deirawan, Hany, Bandyopadhyay, Sudeshna, Ali-Fehmi, Rouba, Dyson, Gregory, Cote, Michele L.
Zdroj: Breast Cancer Research & Treatment; Feb2021, Vol. 185 Issue 3, p831-839, 9p
Abstrakt: Purpose: Markers of inflammation, including crown-like structures of the breast (CLS-B) and infiltrating lymphocytes (IL), have been identified in breast tissue and associated with increased risk of breast cancer (BrCa), however most of this work has been performed in primarily non-Hispanic white women. Here, we examined whether CLS-B and IL are associated with invasive BrCa in African American (AA) women. Methods: We assessed breast biopsies from three 5-year age-matched groups: BrCa-free AA women (50 Volunteer) from the Komen Normal Tissue Bank (KTB) and AA women with a clinically-indicated biopsy diagnosed with benign breast disease (BBD) from our Detroit cohort who developed BrCa (55 BBD-cancer) or did not develop BrCa (47 BBD only, year of biopsy matched to BBD-cancer). Mean adipocyte diameter and total adipose area were estimated from digital images using the Adiposoft plugin from ImageJ. Associations between CLS-B, IL, and BrCa among KTB and Detroit biopsies were assessed using multivariable multinomial and conditional logistic regression models. Results: Among all biopsies, Volunteer and BBD only biopsies did not harbor CLS-B or IL at significantly different rates after adjusting for logarithm of adipocyte area, adipocyte diameter, and BMI. Among clinically-indicated BBD biopsies, BBD-cancer biopsies were more likely to exhibit CLS-B (odds ratio (OR) = 3.36, 95% Confidence Interval (CI): 1.33–8.48) or IL (OR = 4.95, 95% CI 1.76–13.9) than BBD only biopsies after adjusting for total adipocyte area, adipocyte diameter, proliferative disease, and BMI. Conclusions: CLS-B and IL may serve as histological markers of BrCa risk in benign breast biopsies from AA women. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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