| Abstrakt: |
Objective: Lead is a toxic metal that damages neural connections (especially in children) and causes blood and brain diseases. Ellagic acid is a natural phenolic compound that has antioxidant properties. The objective of this study was to evaluate the efficacy of ellagic acid in lead-induced toxicity. Methods: In this study, the effects of lead-induced toxicity on brain cells were investigated. The role of Ellagic acid in its antioxidant properties has also been studied. Levels of glutathione, nitric oxide, malondialdehyde, TNF-α, IL-1B, glutathione reductase, and catalase were evaluated. The amount of delay in rat fall and delay in dark box entry were also investigated. Results: The study found that lead reduced the delay in rat fall, decreased rat entry into the dark box, decreased glutathione, increased malondialdehyde, increased nitric oxide, decreased catalase, superoxide dismutase and glutathione peroxidase, and also increased TNF-α and IL-1B. In all cases, Ellagic acid had a therapeutic role and had a significantly different function to lead in all cases (P < 0.05). Conclusion: The results of a recent study have shown that lead is very harmful to humans and could endanger human life. It has also been extracted from this study that ellagic acid, as a natural compound, is very useful and can alleviate the damaging effects of heavy metals, especially lead, on the human body. [ABSTRACT FROM AUTHOR] |
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