PD-L1 Expression Correlated with p53 Expression in Pediatric Glioblastoma Multiforme.

Autor:	Litak, Jakub, Grajkowska, Wiesława, Szumiło, Justyna, Krukow, Paweł, Maciejewski, Ryszard, Roliński, Jacek, Grochowski, Cezary, Pešić, Milica, Gómez, Pilar Sánchez, Oliver, Lisa
Předmět:	GLIOBLASTOMA multiforme PROGRAMMED death-ligand 1 PEDIATRIC therapy DIAGNOSIS GLIOMAS
Zdroj:	Brain Sciences (2076-3425); Feb2021, Vol. 11 Issue 2, p262, 1p
Abstrakt:	High-grade gliomas are infrequent in the pediatric population compared to adults, nevertheless, mortality and morbidity caused by malignant gliomas in this group of patients remain significant. PD-L1 and PD-1 Immune checkpoints (IC) molecules maintain immunological balance between activation and suppression. Eighteen patients with a histopathological diagnosis of pediatric glioblastoma multiforme (GBM, WHO IV) were studied. In total, PD-L1 expression was detected in 8 patients (44%). The molecular aspect of IC and immunotherapy targeted on PD-1/PD-L1 axis in pediatric population may be a promising adjuvant therapy in pediatric glioblastoma multiform treatment, however, this subject requires further investigation. [ABSTRACT FROM AUTHOR]
Databáze:	Complementary Index
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