| Abstrakt: |
Floating tablets of Mefenamic acid were developed with different concentrations of guar and Xanthan gum by direct compression methodology. The parameters such tapped density, bulk density, Carr's index, Hausner's ratio and angle of repose was found to be in the range and the thickness, weight, variation, hardness, friability of the tablets were found to be in the rang Tablets containing higher amount of guar gum & Xanthan gum usually showed longer total floating time. It ranged from 06 to 6.5 h. At the end of 6 h, F4 showed the best drug release 93.20%. F1, F2, F3, F5, and F6 showed 90.3, 91.7, 89.29, and 83.3% F6 showed the foremost effective sustained release behavior (73.2%) because of the polymer concentration was increased with increased viscosity grade, the percentage drug release got decreased resulting in a sustained drug release pattern over a period of more than 6.5h due to enhance Floatation, Based on present study it absolutely was concluded that floating tablets of mefenamic acid can increase the bioavailability additionally as gastric residence time, and so batter patient compliance may be achieved. It can be concluded that floating tablets are often used as a SR matrix. Due to their superior characteristics. [ABSTRACT FROM AUTHOR] |
