DEMONSTRATION OF INTERCELLULAR IMMUNOFLUORESCENCE AND EPIDERMAL HYSTERESIS IN BULLOUS FIXED DRUG ERUPTION DUE TO PHENOLPHTHALEIN.

Autor: Shelley, Walter B., Schlappner, Otto L. A., Heiss, Harold B.
Předmět:
Zdroj: British Journal of Dermatology; Feb1972, Vol. 86 Issue 2, p118-125, 8p
Abstrakt: We have reported a case of severe bullous erythema multiforme type of fixed drug eruption in which (1) multiple drugs were erroneously first indicated as the cause; (2) a flase positive bullous patch test was obtained and disocovered to be an intracorneal artefacrt, reflecting a new phenomenon, epidermal hysteresis; (3) a relationship to auto-sensitization and pemphigus was discerned by the demonstration of direct intercelluar immunofluorescence in the lower epidermis of the affected fixed sites only; (4) phenolphthalein was finally proven to be the specific cause by double-blind oral challenge. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index