| Autor: |
Zhao, Kaixuan, Li, Shisi, Yi, Peiwei, Guo, Yihao, Yu, Qinqin, Zhu, Cuiling, Feng, Qianjin, Du, Jiang, Zhang, Xiaodong, Feng, Yanqiu |
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| Zdroj: |
European Radiology; Mar2021, Vol. 31 Issue 3, p1569-1577, 9p, 1 Color Photograph, 2 Diagrams, 1 Chart, 3 Graphs |
| Abstrakt: |
Objectives: To investigate the capacity of ultrashort echo time (UTE) T1 mapping to non-invasively assess gadolinium deposition in cortical bone after gadolinium-based contrast agent (GBCA) administration. Methods: Twenty-eight New Zealand rabbits (male, 3.0–3.5 kg) were randomly allocated into control, macrocyclic, high-dose macrocyclic, and linear GBCA groups (n = 7 for each group), and respectively given daily doses of 0.9 ml/kg bodyweight saline, 0.3 mmol/kg bodyweight gadobutrol, 0.9 mmol/kg bodyweight gadobutrol, and 0.3 mmol/kg bodyweight gadopentetate dimeglumine for five consecutive days per week over a period of 4 weeks. After a subsequent 4 weeks of recovery, the rabbits were sacrificed and their tibiae harvested. T1 value of cortical bone was measured using a combination of UTE actual flip angle imaging and variable repetition time on a 7T animal scanner. Gadolinium concentration in cortical bone was measured using inductively coupled plasma mass spectrometry (ICP-MS). Pearson's correlation between R1 value (R1 = 1/T1) and gadolinium concentration in cortical bone was assessed. Results: Bone T1 values were significantly lower in the lower-dose macrocyclic (329.2 ± 21.0 ms, p < 0.05), higher-dose macrocyclic (316.8 ± 21.7 ms, p < 0.01), and linear (296.8 ± 24.1 ms, p < 0.001) GBCA groups compared with the control group (356.3 ± 19.4 ms). Gadolinium concentrations measured by ICP-MS in the control, lower-dose macrocyclic, higher-dose macrocyclic, and linear GBCA groups were 0.04 ± 0.02 μg/g, 2.60 ± 0.48 μg/g, 4.95 ± 1.17 μg/g, and 13.62 ± 1.55 μg/g, respectively. There was a strong positive correlation between R1 values and gadolinium concentrations in cortical bone (r = 0.73, p < 0.001). Conclusions: These results suggest that UTE T1 mapping has the potential to provide a non-invasive assessment of gadolinium deposition in cortical bone following GBCA administration. Key Points: • Changes in T1value related to gadolinium deposition were found in bone after both linear and macrocyclic GBCA administrations. • R1relaxometry correlates strongly with gadolinium concentration in cortical bone. • UTE T1mapping provides a potential tool for non-invasively monitoring gadolinium deposition in cortical bone. [ABSTRACT FROM AUTHOR] |
| Databáze: |
Complementary Index |
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