The PRIAMO study: age- and sex-related relationship between prodromal constipation and disease phenotype in early Parkinson's disease.

Autor: Picillo, Marina, Palladino, Raffaele, Erro, Roberto, Alfano, Rossella, Colosimo, Carlo, Marconi, Roberto, Antonini, Angelo, Barone, Paolo, on behalf of the PRIAMO study group, Morgante, Letterio, Benincasa, D., Quatrale, R., Biguzzi, S., Braga, M., Ceravolo, G., Capecci, M., Meco, G., Caravona, N., Scala, R., De Falco, F. A.
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Zdroj: Journal of Neurology; Feb2021, Vol. 268 Issue 2, p448-454, 7p
Abstrakt: Objectives: To explore the impact of sex and age on relationship between prodromal constipation and disease phenotype in Parkinson's disease at early stages. Methods: A total of 385 Parkinson's disease patients from the PRIAMO study were classified according to the presence of prodromal constipation and followed for 24 months. Multivariable mixed-effect models were applied. All analyses were performed separately for sex (64.1% men) and median age (different by sex: 67 years-old in men and 68 years-old in women). Results: As for sex, prodromal constipation was associated with greater odds of attention/memory complaints and apathy symptoms in women only. As for age, prodromal constipation was associated with lower cognitive and higher apathy scores in older patients only. Conclusions: Prodromal constipation anticipates lower cognitive performances and more severe apathy since the earliest stages in women and older patients. Sex- and age-related heterogeneity of prodromal markers of Parkinson's disease may impact disease phenotype. [ABSTRACT FROM AUTHOR]
Databáze: Complementary Index
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